The Royal
Society

Monday, 11th October 1999

Royal Society Rejects Latest Claims On GM Potatoes

A paper apparently due to be published by Dr Pusztai and Professor Ewen in the Lancet examines the possible toxicity of genetically modified (GM) potatoes by measuring gut responses in rats fed with GM potatoes. The paper is based on experiments flawed in design and implementation and no conclusions can be drawn from it. The comments the Society published in May about alleged experimental evidence of toxic effects remain valid.

Publication of the paper makes Pusztai and Ewen's data and interpretations accessible to a wider audience for further evaluation. The Society first called for the data from this contentious work to be submitted for publication in August 1998.

Close reading of the paper makes it clear that it is based on the work reviewed by the Society in May this year and that it, too, is flawed. Too few animals were used to give statistically significant results for the complex phenomena being examined; the diets used were incompletely controlled; there was no mention of the gut responses in any control group of rats fed a normal, or reduced protein, diet (the latter is important because GM potatoes contain less protein than normal potatoes); and there was, again, a lack of rigour in the experimental design and statistical interpretation.

On the basis of this paper, it is wrong to conclude that there are human health concerns with the process of genetic modification itself, or even with the particular genes inserted into these GM potatoes.


Dr Rebecca Bowden
Senior Manager Science Policy
The Royal Society
6 Carlton House Terrace
London
SW1Y 5AG
tel: 0171 451 2588
fax: 0171 451 2692
e mail: rebecca.bowden@royalsoc.ac.uk
e mail (home): bec@angelrdc.demon.co.uk

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